Activin A more prominently regulates muscle mass in primates than does GDF8

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Activin A more prominently regulates muscle mass in

Activin A more prominently regulates muscle mass in primates than does GDF8 Esther Latres1,*,w, Jason Mastaitis1,*, Wen Fury1, and that it has a more significant role in regulating muscle mass in primates than in mice. The data provide support GDF8 and activin A inhibition increases muscle mass …

Activin A more prominently regulates muscle mass in

Activin A more prominently regulates muscle mass in primates than does GDF8. Activin A more prominently regulates. Activin A and GDF8 inhibition synergistically increase muscle mass in mice.

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REVIEWERS’ COMMENTS: Reviewer #1 (Remarks to the Author)

indeed more important than myostatin in regulating the muscle mass of primates, one would likely expect to see an overt effect following treatment with REGN2477 alone …

Mice with MD Increase Muscle Mass when Three Proteins Are

The result was a moderate recovery of about 20 percent of the animals’ muscle mass. That finding confirmed the proteins’ role in muscle mass maintenance, the team said. Injecting mice with a myostatin inhibitor led to a 45 percent jump in muscle mass, indicating it plays a …

Supraphysiologic Administration of GDF11 Induces Cachexia

Activin A more prominently regulates muscle mass in primates than does GDF8. directly addressed signaling effects found that GDF11 activated the same ActRII/Alk/SMAD2/3 pathway as did myostatin/GDF8, also inducing muscle atrophy and inhibiting muscle differentiation Activin A more prominently regulates muscle mass in primates than does

Supraphysiologic Administration of GDF11 Induces Cachexia

more. Reprints; Top; Increased levels of GDF11 cause increased circulating Activin A and GDF15 in mice; Supraphysiologic levels of GDF11 induce cachexia, anorexia, and muscle loss Activin A more prominently regulates muscle mass in primates than does GDF8. Nat. Commun. 2017; 8: 15153.

GDF-8/Myostatin Quantikine ELISA Kit DGDF80: R&D Systems

Activin A more prominently regulates muscle mass in primates than does GDF8 Authors: E Latres, J Mastaitis, W Fury, L Miloscio, J Trejos, J Pangilinan, H Okamoto, K Cavino, E Na, A Papatheodo, T Willer, Y Bai, J Hae Kim, A Rafique, S Jaspers, T Stitt, AJ Murphy, GD Yancopoulo, J Gromada Nat Commun, 2017;8(0):15153.

A phase I/IItrial of MYO-029 in adult subjects with

A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophy. Authors. Jaspers, Trevor Stitt, Andrew J. Murphy, George D. Yancopoulos, Jesper Gromada, Activin A more prominently regulates muscle mass in primates than does GDF8, Julie Glowacki, Shalender Bhasin, Administration of an activin receptor IIB ligand trap protects

Published in: Annals of Neurology · 2008Authors: Kathryn R Wagner · James L Fleckenstein · Anthony A Amato · Richard J Barohn · K …Affiliation: Johns Hopkins University School of Medicine · University of Oklahoma · Brigham and …About: Biological activity · Adverse effect · Functional testing · Muscular dystrophy · Limb-girdl…

Recombinant Human/Mouse/Rat GDF-8/Myostatin Protein

Activin A more prominently regulates muscle mass in primates than does GDF8 Authors: E Latres, J Mastaitis, W Fury, L Miloscio, J Trejos, J Pangilinan, H Okamoto, K Cavino, E Na, A Papatheodo, T Willer, Y Bai, J Hae Kim, A Rafique, S Jaspers, T Stitt, AJ Murphy, GD Yancopoulo, J Gromada Nat Commun, 2017;8(0):15153.

Blockade of activin type II receptors with a dual anti

Recent work examining the relative contribution of various ligands, activin A, activin B, beyond myostatin, unveiled a strong synergistic response upon blockade of both activin and myostatin (18, 19), with some cross-species difference between mice and primates .

Blockade of activin type II receptors with a dual anti

18. Latres E, et al. (2017) Activin A more prominently regulates muscle mass in primates than does GDF8. Nat Commun 8:15153. 19. Chen JL, et al. (2017) Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease. Proc Natl Acad Sci USA 114:E5266–E5275. 20.

A single ascending‐dose study of muscle regulator ace‐031

ACE‐031 promotes muscle growth by binding to myostatin and other negative regulators of muscle mass. Methods This double‐blind, placebo‐controlled study evaluated the safety, pharmacokinetics, and pharmacodynamics of ACE‐031 in 48 healthy, postmenopausal women randomized to receive 1 dose of ACE‐031 (0.02–3 mg/kg SC) or placebo (3:1).

A phase I/IItrial of MYO-029 in adult subjects with

Safety and tolerability of MYO-029 in adult subjects with muscular dystrophy were the primary outcome measures. a study of creatine monohydrate in multiple muscular dystrophies.5 LGMD includes more than 15 distinct , George D. Yancopoulos, Jesper Gromada, Activin A more prominently regulates muscle mass in primates than does GDF8,

Published in: Annals of Neurology · 2008Authors: Kathryn R Wagner · James L Fleckenstein · Anthony A Amato · Richard J Barohn · K …Affiliation: Johns Hopkins University School of Medicine · University of Oklahoma · Brigham and …About: Biological activity · Adverse effect · Functional testing · Muscular dystrophy · Limb-girdl…

Activin A ELISA DAC00B from R&D Systems | Biocompare.com

Latres E, Mastaitis J, Fury W, Miloscio L, Trejos J, Pangilinan J, Okamoto H, Cavino K, Na E, Papatheodorou A. Activin A more prominently regulates muscle mass in primates than does GDF8. Nat Commun . 2017 Apr 28;8:15153.

Therapeutic strategies against muscular dystrophy and

In primates, it has been reported that activin A plays a more important role than myostatin in determining skeletal muscle mass [12]. Blockade of myostatin and related TGF-β superfamily members is a promising therapeutic strategy for restoring muscle mass and strength in muscle wasting disorders like muscular dystrophy, sarcopenia, and cachexia.