Time Is Money: Optimizing the Scheduling of Nivolumab The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated.
Time Is Money: Optimizing the Scheduling of Nivolumab Mark J. Ratain, The University of Chicago, Chicago, IL Daniel A. Goldstein, Rabin Medical Center, Petach Tikvah, Israel, and University of North Carolina at Chapel Hill, Chapel Hill, NC The checkpoint inhibitors have revolutionized the treatment
“Patients who respond to nivolumab have an additional benefit because clearance decreases when disease status improves. This means that the trough concentration will increase over time as clearance decreases (mean decrease, approximately 25%) and also implies that a reduction in either dose or frequency of dosing will maintain therapeutic trough concentrations.
Nivolumab demonstrated efficacy in clinical trials for various types of cancer. A time‐varying clearance was identified for nivolumab. We show that the change of clearance over time is associated with the post‐treatment effects: clearance decreases when disease status improves.
W hereas traditional drug development utilizes standard tools of randomization, pharmacokinetic data, and blood-based biomarkers to optimize dosing, oncology has primarily utilized safety data (i.e., maximally tolerated dose) to guide dose selection.
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Alexander A. Vinks, Therapeutic Optimization as Part of the Precision Medicine Paradigm, Clinical Pharmacology & Therapeutics, 99, 4, (340-342), (2016). Wiley Online Library M Stroh and BL Lum , Should Therapeutic Drug Monitoring for Monoclonal Antibodies Remain the Exception or Become the Norm? , Clinical Pharmacology & Therapeutics , 100 , 3 , (215-217) , (2016) .
Daniel A Goldstein John F Acquavella Rhonda M Mannion Donna R Farmer J Toxicol Clin Toxicol 2002 ;40(7):885-92 Monsanto Company C2SE, 800 N. Lindbergh Blvd., St. Louis, MO 63167, USA.
Optimization of labor as a result of inventory and scheduling integration allows you to redistrib-ute your resources effec-tively. Improved produc-tion levels from in-tegrated scheduling resulted in $120,000 in direct labor cost savings LOST: Production time due to extended change over times
The Intrinsic Link between Time and Money: How to Optimise your Productivity as an Entrepreneur. If you are able to understand the intrinsic link that exists between time and money, however, you may be well-placed to become a productive, profitable and ultimately successful entrepreneur.