A review of the evidence concerning hepatic glutathione depletion and susceptibility to hepatotoxicity after paracetamol overdose

A review of the evidence concerning hepatic glutathione

Dec 23, 2011 · In our recent review published in this journal, we reviewed the data supporting an association between drug-related induction of the cytochrome P450 isoenzyme system and paracetamol-related hepatotoxicity. 15 This paper reviews the literature to determine whether factors that are currently considered to increase risk of hepatotoxicity following paracetamol overdose due to depletion of …

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A review of the evidence concerning hepatic glutathione

A review of the evidence concerning hepatic glutathione depletion and susceptibility to hepatotoxicity after paracetamol overdose production.27,30 Glutathione depletion also correlates with

A review of the evidence concerning hepatic glutathione

In the UK there are two treatment lines on this nomogram, with the lower treatment line used for individuals felt to be at ‘high risk’ of paracetamol-related hepatotoxicity either as a result of induction of cytochrome P450 isoenzymes or reduction of intrahepatic glutathione.

Published in: Open Access Emergency Medicine · 2011Authors: Sarbjeet S Kalsi · Paul I Dargan · W Stephen Waring · David M WoodAffiliation: National Health Service

A review of the evidence concerning hepatic glutathione

In the UK there are two treatment lines on this nomogram, with the lower treatment line used for individuals felt to be at ‘high risk’ of paracetamol-related hepatotoxicity either as a result of induction of cytochrome P450 isoenzymes or reduction of intrahepatic glutathione.

A review of the evidence concerning hepatic glutathione

A review of the evidence concerning hepatic glutathione depletion and susceptibility to liver toxicity after paracetamol overdose

What dose of paracetamol for older people? | Drug and

A review of the evidence concerning hepatic glutathione depletion and susceptibility to hepatotoxicity after paracetamol overdose. Open Access Emerg Med2011; 3: 87 – 96.

Paracetamol overdose – History and exam | BMJ Best Practice

Long-term treatment with cytochrome P450 2E1 inducers (e.g., phenobarbital, isoniazid) or long-standing alcohol abuse may increase the risk of liver damage following paracetamol overdose. Kalsi SS, Dargan PI, Waring WS, et al. A review of the evidence concerning hepatic glutathione depletion and susceptibility to hepatotoxicity after paracetamol overdose.

Effects of nutritional status on acetaminophen measurement

A review of the evidence concerning hepatic glutathione depletion and susceptibility to hepatotoxicity after paracetamol overdose. Open Access Emerg Med OAEM. 2011;3: 87 – 96. [Google Scholar]]. Several pathophysiological mechanisms might be affected.

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Paracetamol (acetaminophen) overdose and acetylcysteine

P450 liver isoenzyme induction increase the risk of liver toxicity after paracetamol overdose? Open Access Emerg Med 2011;3:69–76. 4 Kalsi SS,Dargan PI,Waring WS,Wood DM.A review of the evidence concerning hepatic glutathione depletion and susceptibility to liver toxicity after paracetamol overdose. Open Access Emerg Med 2011;3:87–96.

Risk assessment of hepatotoxicity among tuberculosis and

Regarding the C-reactive protein results, the percentage of positive tests was very high among coinfected patients (40%) compared with the control (15%). The interactions between parameters related to alcohol consumption and intake of antioxidant foods showed a slight decrease in activity compared with interactions without food.

Acetaminophen overdose – History and exam | BMJ Best Practice

A review of the evidence concerning hepatic glutathione depletion and susceptibility to hepatotoxicity after paracetamol overdose. Kalsi SS, Dargan PI, Waring WS, et al. A review of the evidence concerning hepatic glutathione depletion and susceptibility to hepatotoxicity after paracetamol overdose.

Paracetamol (acetaminophen) overdose and acetylcysteine

Kalsi SS, Dargan PI, Waring WS, Wood DM. A review of the evidence concerning hepatic glutathione depletion and susceptibility to liver toxicity after paracetamol overdose…

Papers with the keyword treatment acetaminophen poisoning

A review of the evidence concerning hepatic glutathione depletion and susceptibility to hepatotoxicity after paracetamol overdose. Sarbjeet S Kalsi, Paul I Dargan, W Stephen Waring, David M Wood Paracetamol (acetaminophen) poisoning is common throughout the world.

Paracetamol (acetaminophen) overdose and acetylcysteine

The Prescott nomogram, Does cytochrome P450 liver isoenzyme induction increase the risk of liver toxicity after paracetamol overdose? Waring WS, Wood DM. A review of the evidence concerning hepatic glutathione depletion and susceptibility to liver toxicity after paracetamol overdose.

Published in: British Journal of Clinical Pharmacology · 2012Authors: W Stephen WaringAbout: Drug overdose · Acetylcysteine · Risk assessment · Acetaminophen