CPP-Assisted Intracellular Drug Delivery, What Is Next?

[PDF]

CPP-Assisted Intracellular Drug Delivery, What Is Next?

of the therapeutic agents with CPPs via charge complexation. Figure1illustrates such CPP-assisted strategies in achieving intracellular delivery of the drug payloads. 2.1. Covalent Conjugation of Therapeutic Agents with CPP The commonly used strategy for CPP-assisted drug delivery is by covalent conjugation,

CPP-Assisted Intracellular Drug Delivery, What Is Next?

However, non-specific CPP-mediated cell penetration into normal tissues can lead to widespread organ distribution of the payloads, thereby reducing the therapeutic efficacy of the drug and at the same time increasing the drug-induced toxic effects.

CPP-Assisted Intracellular Drug Delivery, What Is Next

For the past 20 years, we have witnessed an unprecedented and, indeed, rather miraculous event of how cell-penetrating peptides (CPPs), the naturally originated penetrating enhancers, help

CPP-Assisted Intracellular Drug Delivery, What Is Next?

The CPP-assisted intracellular delivery of large compounds was so overwhelmingly effective that these peptides [2,11,15,16,17,18,19,20,21,22] were given the unique name of “Trojan horse” in their associated delivery systems.

CPP-Assisted Intracellular Drug Delivery, What Is Next?

However, non-specific CPP-mediated cell penetration into normal tissues can lead to widespread organ distribution of the payloads, thereby reducing the therapeutic efficacy of the drug and at the same time increasing the drug-induced toxic effects.

Cell penetrating peptide-modified pharmaceutical

INTRACELLULAR DELIVERY OF PHARMACEUTICAL NANOCARRIERS BY CPPs. CPPs, including TATp, have been widely exploited for the intracellular delivery of different size cargoes (peptides, proteins, genetic material, antibodies, imaging agents, and toxins to nanoparticles and liposomes) in a range of cell types both in vitro and in vivo.

Published in: Biopolymers · 2008Authors: Vladimir P TorchilinAffiliation: Northeastern UniversityAbout: Gene delivery · DNA · Drug carrier

Cell penetrating peptide‐modified pharmaceutical

Xinke Zhang, Xue Zhang and Fengshan Wang, Intracellular transduction and potential of Tat PTD and its analogs: from basic drug delivery mechanism to application, Expert Opinion on Drug Delivery, 10.1517/17425247.2012.663351, 9, 4, (457-472), (2012).

Published in: Biopolymers · 2008Authors: Vladimir P TorchilinAffiliation: Northeastern UniversityAbout: Gene delivery · DNA · Drug carrier

Uptake Mechanism and Direct Translocation of a New CPP for

Next Article Table of Contents. Uptake Mechanism and Direct Translocation of a New CPP for siRNA Delivery Drug Delivery 2017 24 (2), 45-55. Spontaneous Membrane Translocating Peptides: The Role of Leucine-Arginine Consensus Motifs CPP-Assisted Intracellular Drug Delivery, What Is Next? Junxiao Ye, Ergang Liu, Zhili Yu,

Intracellular localisation of proteins to specific

Intracellular protein delivery is a promising means to manipulate cellular function since proteins have key roles in cellular processes and thus are good therapeutic agents [1 Fu A, Tang R, Hardie J, et al. Promises and pitfalls of intracellular delivery of proteins. Bioconjug Chem. 2014;25: 1602 – 1608.

Journal of Drug Targeting – Taylor & Francis

Intracellular protein delivery is a promising means to manipulate cellular function since proteins have key roles in cellular processes and thus are good therapeutic agents [1 Fu A, Tang R, Hardie J, et al. Promises and pitfalls of intracellular delivery of proteins.

Mechanistic aspects of CPP-mediated intracellular drug

In recent years, cell-penetrating peptides have proven to be an efficient intracellular delivery system. The mechanism for CPP internalisation, which first involves interaction with the extracellular matrix, is followed in most cases by endocytosis and finally, depending on the type of endocytosis, an intracellular …

Intracellular Cargo Delivery Using Tat Peptide and Derivatives

Despite these improvements, intracellular delivery is hampered by the stable drug retention of the liposomes, which diminishes the efficacy of the liposomal drug.

Cell-penetrating ‘nanodrills’ show promise for

«The fine-tuning of amino acids imparted versatile properties like flexibility, self-assembly, higher drug loading, biodegradability and biocompatibility for effective intracellular delivery of

Intracellular drug delivery by poly(lactic-co-glycolic

Several studies have investigated the mechanism of intracellular drug delivery by PLGA NPs. It is generally thought that PLGA NPs are taken up by endocytosis and then release the drug at intracellular …