Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

Small extracellular vesicles secreted from senescent cells

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 Article (PDF Available) in Nature Communications 8 · June 2017 with 72 Reads

Small extracellular vesicles secreted from senescent cells

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 (Hara Lab, in Nature Commun) Cellular senescence, a state of irreversible cell cycle arrest, prevents the proliferation of cells at risk for neoplastic transformation.

Small extracellular vesicles secreted from senescent cells

However, the altered secretome of senescent cells can promote the growth of the surrounding cancer cells. Although extracellular vesicles (EVs) have emerged as new players in intercellular communication, their role in the function of senescent cell secretome has been largely unexplored.

Cellular Senescence: The Sought or the Unwanted?: Trends

Senescent fibroblasts generated by various stimuli, particularly those produced from genotoxic stress including chemotherapy, radiation, and replicative exhaustion, promote the proliferation, migration, and invasion of cancer cells in vitro, as demonstrated by coculture data from breast, pancreatic, and squamous cell carcinoma studies

(PDF) Emerging roles of extracellular vesicles in cellular

Senescent cells secrete more EphA2 and DNA via EVs, which can promote cancer cell proliferation and inflammation, respectively.

Project for Cellular Senescence|Laboratories|Cancer Institute

Cellular senescence is the state of irreversible cell cycle arrest provoked by a variety of potentially oncogenic stimuli, such as telomere shortening, DNA damage or activation of certain oncogenes. Cellular senescence appears to be acting as a barrier to cancer, preventing damaged cells from undergoing aberrant proliferation.

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Emerging roles of extracellular vesicles in cellular

that extracellular vesicles (EVs) are important mediators of the effects of senescent cells on their microenvironment. Senescent cells secrete more EphA2 and DNA via EVs, which can promote cancer cell proliferation and inflammation, respectively. Extracellular vesicles secreted from DNA-damaged cells can also affect telomere regulation.

Cellular Senescence: The Sought or the Unwanted

Senescent fibroblasts generated by various stimuli, particularly those produced from genotoxic stress including chemotherapy, radiation, and replicative exhaustion, promote the proliferation, migration, and invasion of cancer cells in vitro, as demonstrated by coculture data from breast, pancreatic, and squamous cell carcinoma studies 18, 62, 63.

Pharmacological evaluation of new bioavailable small

Pharmacological evaluation of new bioavailable small molecules targeting Eph/ephrin interaction when ephrin-A1 was discovered to stimulate TNF-α induced angiogenesis through EphA2 R. Okada, A. Takahashi, D. Virya Chen, S. Watanabe, E. HaraSmall extracellular vesicles secreted from senescent cells promote cancer cell proliferation

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The extracellular vesicles secreted by lung cancer cells

The extracellular vesicles secreted by lung cancer cells in radiation therapy factors or tumor suppressors, and promote the proliferation of cancer cells. It has been Cells The lung cancer cell lines A549 and NCI-H1299 cells, HEK293 and endothelial cells

Recombinant Human EphA2 Protein, CF 3035-A2-100: R&D …

Citations for Recombinant Human EphA2 Protein, CF R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Aging Biology | Osaka University Immunology Frontier

Thus, both apoptosis and cellular senescence are thought to act as important tumor suppression mechanisms. Unlike apoptotic cells, however, senescent cells remain viable for long periods of time and accumulate with increasing age in various organs and tissues in vivo.

Recombinant Mouse EphA2 Fc Chimera Protein, CF

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 Authors: M Takasugi, R Okada, A Takahashi, D Virya Chen, S Watanabe, E Hara Nat Commun, 2017;8(0):15729.

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Contribution of Extracellular Vesicles to Cancer

Extracellular vesicles (EVs) are microvesicles secreted from cells with critical roles in cell-to-cell communication. Over the past three decades, EV biology has been characterized by many researchers. Importantly, EVs promote many steps of cancer progression, including cancer cell proliferation, metastasis, formation of pre-metastasis niches, and