Drosophila p53 preserves genomic stability by regulating cell death

Drosophila p53 preserves genomic stability by regulating

Apr 15, 2003 · In Drosophila, programmed cell death is governed by apoptosis activators mapping to a genomic interval referred to as the Reaper region . Several lines of evidence implicate one gene in this region, reaper ( rpr ), as a direct target of, and effector for, Dmp53 action in vivo .

Drosophila p53 preserves genomic stability by regulating

Together, these results uncover important genomic consequences resulting from failures in p53-mediated cell death and establish the principle that preservation of genomic stability by p53 proteins can derive entirely from apoptotic determinants rather than cell-cycle checkpoint functions.

Published in: Proceedings of the National Academy of Sciences of the United States of America · 2003Authors: Naoko Sogame · Misoo Kim · John M AbramsAffiliation: University of Texas Southwestern Medical CenterAbout: Adaptive response · Ionizing radiation · Genome instability · Gene family · Drosophila …

Drosophila p53 preserves genomic stability by regulating

Abstract. When animal cells are exposed to stressful conditions, the tumor suppressor protein p53 restrains growth by promoting an arrested cell cycle or initiating a cell death program.

Published in: Proceedings of the National Academy of Sciences of the United States of America · 2003Authors: Naoko Sogame · Misoo Kim · John M AbramsAffiliation: University of Texas Southwestern Medical CenterAbout: Adaptive response · Ionizing radiation · Genome instability · Gene family · Drosophila …

Drosophila p53 preserves genomic stability by regulating

To study its functions in vivo we produced a targeted mutation at the Drosophila p53 (Dmp53) locus. We show that Dmp53 is required for damage-induced apoptosis but not for cell-cycle arrest. Dmp53 function is also required for damage-induced transcription of two …

Drosophila p53 preserves genomic stability by regulating

When animal cells are exposed to stressful conditions, the tumor suppressor protein p53 restrains growth by promoting an arrested cell cycle or initiating a cell death program.

Compensatory Proliferation in Drosophila – cell.com

Collectively, our experiments imply that dp53 serves as a master coordinator of tissue repair in imaginal discs, regulating both cell-autonomous and non-cell-autonomous cell-cycle arrests, the expression of the pattern-regulating genes wg and dpp, and compensatory cell proliferation and growth.

Interplay of cell proliferation and cell death in

Recent studies have also revealed that tissue injury responses occur not only locally but also systemically, even in the uninjured region. Genetic studies in Drosophila have demonstrated the dynamic role of the cell death-induced tissue response in the reconstruction of damaged tissues.

Published in: Development Growth & Differentiation · 2014Authors: Soshiro Kashio · Fumiaki Obata · Masayuki MiuraAffiliation: University of TokyoAbout: Imaginal disc · Programmed cell death

Drosophila ATM and Mre11 Are Essential for the – Genetics

To test the first hypothesis, we took advantage of the fact that a p53 mutation is able to suppress cell death in the wing discs of both tefu −/− and mre11 −/− animals (our unpublished data). In addition, 4000 rad of irradiation did not result in a marked increase of apoptosis in the discs of …

Published in: Genetics · 2005Authors: Xiaolin Bi · Min Gong · Deepa Srikanta · Yikang S RongAffiliation: National Institutes of HealthAbout: Mitosis · Mutagenesis · Endodeoxyribonucleases · DNA damage

Drosophila p53 preserves genomic stability by regulating

Apr 15, 2003 · Drosophila p53 preserves genomic stability by regulating cell death. Sogame N(1), Kim M, Abrams JM. Author information: (1)Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA.

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of Things Past – cell.com

a transcription factor that regulates p53 transcription, or whether Dronc has an unknown biochemical activity that alters transcription in a protease-

Published in: Current Biology · 2006Authors: Nirao M ShahAffiliation: University of California San Francisco

A p53 enhancer region regulates target genes through

Drosophila p53 preserves genomic stability by regulating cell death. Proc Natl Acad Sci 100: 4696 – 4701.

Published in: Genes & Development · 2013Authors: Nichole Link · Paula Kurtz · Melissa Oneal · Gianella Garciahughes · John M AbramsAffiliation: University of Texas Southwestern Medical CenterAbout: Chromatin · Regulation of gene expression · Chromosome conformation capture · Plas…