Effect of phorbol ester (PMA) on antioxidant enzyme expression in TGF-beta 1-induced apoptosis in primary cultures of hepatocytes.

Effect of phorbol ester (PMA) on antioxidant enzyme

It has been described that the antioxidant enzyme systems play an important role in the control of apoptosis and that the apoptogenic ability of TGF-β1 is through the inhibition of antioxidant enzyme expression in cultured hepatocytes [Y. Kayanoki, J. Fujii, K. Suzuki, S. Kawata, Y. Matsuzawa and N. Taniguchi, Suppression of antioxidative enzyme expression by transforming growth factor-β 1 in rat …

Published in: Biofactors · 1998Authors: Carmen Diezfernandez · Nuria Sanz · Armin Wolf · Maria CascalesAffiliation: Novartis

Effect of phorbol ester (PMA) on antioxidant enzyme

Effect of phorbol ester (PMA) on antioxidant enzyme expression in TGF- β1-induced apoptosis in primary cultures of hepatocytes

Effect of phorbol ester (PMA) on antioxidant enzyme

Read «Effect of phorbol ester (PMA) on antioxidant enzyme expression in TGF- \beta 1-induced apoptosis in primary cultures of hepatocytes, BioFactors» on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

Published in: Biofactors · 1998Authors: Carmen Diezfernandez · Nuria Sanz · Armin Wolf · Maria CascalesAffiliation: Novartis

Attenuating effects of heat shock against TGF-β1-induced

Moreover, suppression of antioxidant enzyme gene expression, together with the appearance of oxidative stress, is involved in the process of TGF-β1 induction of apoptosis , . Nuclear factor-κB (NF-κB), an inducible eukaryotic transcription factor of the rel family, normally exists in an inactive cytoplasmic complex, bound to inhibitory proteins of the IκB family.

Antioxidant Regulation of Phorbol Ester-Induced Adhesion

The effect of α-lipoate pretreatment on PMA-induced expression of VCAM-1 in ECV cells was determined . The constitutive expression of VCAM-1 in ECV cells was observed to be very low. PMA-induced VCAM-1 expression was down-regulated by α-lipoate treatment in a dose dependent manner.

Effect of phorbol ester treatment on receptor-mediated

Aug 15, 1989 · However, after a 5 min pre-treatment, thrombin-induced secretion alone was inhibited, whereas PMA plus GTP[S]/NaF-induced release remained greater than additive. [32P]Phosphatidate formation in response to all three agents, in contrast, was inhibited by …

(PDF) The effect of non-genotoxic carcinogens

The effect of non-genotoxic carcinogens, phenobarbital and clofibrate, on the relationship between reactive oxygen species, antioxidant enzyme expression and apoptosis

The effect of phorbol esters and diacylglycerol on

Dec 25, 1986 · Like insulin, PMA provokes a concentration and time-dependent decrease of mRNA coding for that enzyme that is due to an inhibition of P-enolpyruvate carboxykinase gene transcription. This effect of PMA is rapid, reversible, specific for phorbol esters known to be active in other systems, and it does not require on-going protein synthesis.

Effect of phorbol esters on protein kinase C-zeta.

Protein kinase C-zeta (PKC-zeta) is a member of the protein kinase C gene family which using in vitro preparations has been described as being resistant to activation by phorbol esters. PKC-zeta was found to be expressed in several cell types as an 80-kDa protein.

Published in: Journal of Biological Chemistry · 1992Authors: D K Ways · P P Cook · C Webster · Peter J ParkerAbout: Signal transduction · Protein kinase C · Cell culture · Enzyme

Enhancement of phorbol ester-induced protein kinase

Since PMA is known to cause cytosol-to-membrane shift of calcium-activated, phospholipid-dependent protein kinase (protein kinase c, PKC) in human neutrophils, we investigated the role of PAF in modifying PMA-induced PKC activation/translocation.

Published in: Journal of Cellular Physiology · 1988Authors: Ella S StittAffiliation: Vanderbilt UniversityAbout: Platelet-activating factor

Phorbol ester stimulates a protein kinase C–mediated

First, both phorbol myristate acetate (PMA) and diacylglycerol, 2 activators of protein kinase C (PKC), were found to stimulate calcium entry into RBCs, whereas 4α-phorbol ester, an …

Published in: Blood · 2002Authors: Dina A Andrews · Lu Yang · Philip S LowAbout: Okadaic acid · Calcium · Phosphoric monoester hydrolases · Protein kinase A · Potass…

Effect of phorbol myristate acetate on alpha 1-adrenergic

Abstract. We studied the ability of norepinephrine to stimulate [3H]inositol trisphosphate production and calcium mobilization in rat-1 fibroblasts stably expressing the cloned alpha 1-adrenergic subtypes and their sensitivity to phorbol-12-myristate-13-acetate (PMA).

Phorbol ester treatment inhibits phosphatidylinositol 3

CD28 is a costimulatory receptor found on the surface of most T lymphocytes. Engagement of CD28 induces interleukin 2 (IL-2) production and cell proliferation when combined with an additional signal such as treatment with phorbol ester, an activator of protein kinase C.